MarkVCID Consortium common protocols are now available here
Information about the previous annual meeting is now online here
Nov 7, 2018 – San Diego, CA
Society for Neuroscience features MarkVCID
NINDS Neurodegeneration Program Director & ADRD Program Lead Dr. Rod Corriveau presented the first wave of MarkVCID biomarker kits that are moving onto multi-site testing at the Society for Neuroscience (SfN) conference.
Imaging- and fluid-based kits include: White Matter Hyperintensity, Cerebrovascular Reactivity, Peak Skeletonized Mean Diffusivity, Arteriolosclerosis (WMH & diffusion anisotropy), Longitudinal WMH from 3-D FLAIR, Endothelial Inflammation, and Endothelial Signaling Kit.
[Read more – PPT]
July 25, 2018 – Chicago, Illinois
Alzheimer’s Association International Conference® (AAIC®) Previews MarkVCID’s First Wave of Biomarkers
NINDS Neurodegeneration Program Director & ADRD Program Lead Dr. Rod Corriveau presented MarkVCID's first wave of potential small vessel VCID biomarkers at AAIC that will be validated and prepared for large scale multi-site clinical research including interventional trials
Based on the Coordinating Center PI, External Advisory Committee, and NINDS leadership's review, five imaging-based and two fluid-based biomarker kits presented the most compelling rationale, scientific rigor, connection to small vessel disease, cognitive outcomes, and clinical trial readiness. After multi-site testing begins for the first wave, additional biomarker kits will be considered on a rolling basis.
To support the effort to identify and validate biomarkers, the Consortium has agreed to collaborate on a series of core MRI protocols, collect a core set of VCID-related clinical and cognitive data elements and biosamples, and adopt fluid sample collection best practices. Participating sites have also implemented sharing policies and procedures that ensure seamless cross-validation of biomarkers and exchange of data.
[Read more about AAIC®]
May 7-8, 2018 – Bethesda, Maryland
MarkVCID joins the NHLBI Working Group for VCID
Several MarkVCID investigators participated in the National Heart, Lung, and Blood Institute’s (NHLBI) Working Group for Vascular Contributions to Cognitive Impairment and Dementia. The workshop aimed to “identify research priorities that complement and expand on the VCID Research Milestones developed by the 2016 Alzheimer’s Disease-Related Dementia (ADRD) Summit.” The working group’s contributions will help guide NHLBI’s efforts to support researchers in the field for the next 5-10 years.
MarkVCID PI Dr. Steven Greenberg (MGH) presented on the development and validation of biomarkers to study VCID in the MarkVCID Consortium. PI Dr. Sudha Seshadri (CHARGE) presented on atherosclerosis and dementia as known vascular contributing factors for dementia; and PI Dr. Julie Schneider (Rush) presented the impact of multiple vascular pathologies on trajectories and patterns of cognitive decline. Co-chairs Drs. Berislav Zlokovic (USC) and Rebecca Gottesman (EAC) moderated the workshop and remarked on current research in VCID and epidemiological studies.
March 12, 2018 - Rochester, Minnesota
Mayo Clinic Announces Gainey Named Visiting Professor
Mayo Clinic Department of Neurology and the Division of Cerebrovascular Diseases announced Dr. Steven M. Greenberg as the 2017 Gainey Named Visiting Professor. In his presentation, Dr. Greenberg discussed aspects of the MarkVCID consortium and its aim to deliver high-quality biomarkers to increase understanding and treatment of small vessel disease. Dr. Greenberg also led a seminar in adjunct with the Mayo Clinic’s Department of Neurology, Neurosurgery and Health Sciences at Grand Rounds to staff, residents, and fellows.
The Departments of Neurology, Neurosurgery and Health Sciences Research at the Mayo Clinic oversee a Named Visiting Professorship in Stroke and Related Diseases provided by the late Mr. Daniel C. Gainey.
For more information about the Department, click here.
February 2, 2018 - Los Angeles, California
NBCUniversal Telemundo Features MarkVCID Research Site USC’s Alzheimer’s Study
University of Southern California investigator Dr. John Ringman discusses a rare genetic mutation that causes disease in young people.The research site will enroll participants from these families in MarkVCID to assess small vessel disease in this form of Alzheimer’s Disease. [See feature in Spanish]
Feb 2018 – Journal articles
MarkVCID Research featured in Frontiers in Neurology and Journal of Magnetic Resonance
University of Southern California MarkVCID PI Dr. Danny JJ Wang and co-investigators refer to the first stage (UH2) of MarkVCID research in publications including:
January 25, 2018 - Los Angeles Convention Center
MarkVCID at International Stroke Conference 2018
On Jan 25, 2018, the AHA International Stroke Conference features the MarkVCID Consortium as a part of its 2 ½-day agenda covering over 1,500 presentations in 21 categories that emphasize basic, clinical and translational sciences.
The panel discussion entitled, “Marking Vascular Cognitive Impairment: MarkVCID” begins with an overview of the Consortium goals, science, and structure from MarkVCID Coordinating Center PI Steven M. Greenberg. The panel invites Consortium PI’s Danny JJ Wang (University of Southern California) to discuss multimodal MRI biomarkers and Donna Wilcock (University of Kentucky) to discuss fluid-based biomarkers of cerebral small vessel disease. Participants learn about the challenges and successes of developing shared protocols, validating across sites, and achieving multicenter reliability for the discovery of clinical trial-ready biomarkers. Co-moderators include Johns Hopkins Bloomberg School of Public Health Faculty Rebecca Gottesman and Lille University Neurology & Stroke Centre Lead Investigator Charlotte Cordonnier.
Sharing a perspective from outside the Consortium, Institute for Stroke and Dementia Research Director Martin Dichgans speaks about international biomarker programs and collaboration opportunities. [For more information about ISC, click here]
January 22-23, 2018 - USC Keck School of Medicine
Annual MarkVCID Conference
Preceding the AHA International Stroke Conference, the MarkVCID Consortium holds its second annual conference at the University of Southern California Keck School of Medicine. Nearly 100 contributors join from research sites nationwide to discuss the development of candidate biomarkers and treatments for vascular cognitive impairment. [Read more]
July 11, 2017 – Stroke Journal
William M. Feinberg Award for Excellence in Clinical Stroke
Stroke (Journal of the American Heart Association) features the MarkVCID Consortium in “Big Pictures and Small Vessels,” by Steven M. Greenberg; September 2017, Volume 48, Issue 9 [Read more]
June 1, 2017 - Toronto, Canada
MarkVCID Participates in Harness Initiative Conference
MarkVCID Consortium Program Director & NINDS AD/ADRD Program Lead Rod Corriveau and Coordinating Center PI Steven Greenberg present the Consortium’s background and goals at the HARNESS Initiative Conference. [Read more]
March 10, 2017 - Houston, Texas
MarkVCID Kickoff Meeting
The MarkVCID Consortium held its first Annual Meeting on February 20-21, 2017 in Houston, Texas just prior to the International Stroke Conference.
Wednesday, February 22, 2017
NIH MarkVCID Press Release
"NIH consortium takes aim at vascular disease-linked cognitive impairment and dementia MarkVCID brings team science approach to small vessel disease biomarkers in the brain." [Read more]
February 20-21, 2017 – Houston, Texas
First Annual MarkVCID Conference
The MarkVCID Consortium holds its first annual conference bringing together investigators from seven research sites nationwide.