Annual Conference 2025

2025 Annual MarkVCID Conference

MarkVCID 2025 Annual Conference Attendees (Apr. 28-29, 2025)

The Consortium convened in person on April 28–29 in Chicago, IL. Major discussion topics included the baseline analyses of each imaging biomarker kit, the instrumental re-validation of the Neurofilament Light (NfL) biomarker, and a review of clinical and imaging data collection across sites.
Guest speakers from outside the Consortium provided valuable insights and lessons learned from disease-modifying trials in small vessel disease (SVD), stroke, and Alzheimer’s disease (AD), prompting thoughtful discussions on how to translate those lessons into ongoing efforts.
The Consortium also explored Chicago together on a scenic boat tour, offering a unique perspective on the city’s rich history and architecture.

Presentations

Introductions & Consortium Updates

Overview & Goals
Steve Greenberg, MD, PhD

Operational Data Overview
Lida Mazina

Data QC & Imaging Updates
Karl Helmer, PhD

Biomarker Kit Statistical Analyses
Lisa Wruck, PhD

AD Biomarkers & Next Steps
Pia Kivisakk, MD, PhD

MarkVCID Current & Future
Steve Greenberg, MD, PhD

Guest Speakers

SVD Disease-Modifying Trials
Rebecca Gottesman, MD, PhD

Lessons Learned from Stroke Trials
Pooja Khatri, MD

Lessons Learned from AD Disease-Modifying Trials
John Sims, MD

Kit Presentations

Kit leads presented an overview of each primary biomarker, discussed objectives, and shared initial analyses and dissemination plans. ARTS, CVR, FW, and PSMD analyses included a summary of population baseline characteristics, distribution of biomarkers and correlation among biomarkers, association between baseline biomarker results and vascular risk factors, and association between baseline biomarker results and cognition at baseline. NfL preliminary analyses included a review of instrumental validation methods and results.

MRI Arteriosclerosis
Konstantinos Arfanakis, PhD

MRI Cerebrovascular Reactivity
Hanzhang Lu, PhD

MRI Free Water
Pauline Maillard, PhD; Arvind Caprihan, MD

MRI Peak Skeletonized Mean Diffusivity
Claudia Satizabal, PhD

Plasma Neurofilament Light & Instrumental Validation
Tiffany Kautz, PhD