University of Kentucky

UkySite ImageSmall vessel disease biomarkers in a longitudinally-followed "stroke-belt" cohort


Small vessel disease (SVD) is the leading cause of vascular cognitive impairment and dementia (VCID), and is also a common co-morbidity with Alzheimer’s disease (AD). Our group has identified specific inflammation and angiogenesis markers in the plasma and cerebrospinal fluid of our longitudinal cohort of individuals with cerebrovascular disease and cognitive impairment. These candidate fluid biomarkers discriminate SVD well in the subset of our cohort that we have analyzed. In this application, we have a plan for developing our candidate biomarkers and validating them through the UH2 phase as an individual research group, and also through the UH3 part as a member of the consortium. Our group brings significant strengths that will help synergize and move the consortium as a whole forward in our collective goal of developing biomarkers that are ready for large scale clinical trials and FDA qualification. These strengths include a well characterized, longitudinal cohort supported through our ADC and other NIH initiatives, our long history of active participation in consortia providing the experience and infrastructure needed to ensure success in this UH2/UH3 mechanism, our history of data sharing, resource sharing including samples, recruitment of research participants for longitudinal studies, and our foundation in basic and translational science.



Investigators Information

PI: Donna Wilcock, PhD
Associate Professor of Neurology
University of Kentucky Research Foundation


MPI: Gregory Jicha, MD, PhD
Professor of Neurology
University of Kentucky Research Foundation

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