MarkVCID1 Protocols & Resources
MarkVCID1 Manual of Operating Procedures (v2.5.20)
- Clinical Data Measures Overview (v2.16.21)
- Case Report Forms
- Neuropsychological Battery (NP) In-person Visit Guidelines
- Recorded NP Battery Training Webinar for in-person administration
(Linked file auto-downloads to your computer. Please view in presentation mode to hear audio.)
- Evaluator's Manual for the Neuropsychological Battery (v8.28.18)
- Neuropsychological Battery Worksheets (v11.19.18)
- Recorded NP Battery Training Webinar for in-person administration
- NP Remote Administration Guidelines
- Recorded NP Battery Training Webinar for remote administration (11.2.20)
- Evaluator’s Manual for the Neuropsychological Battery (v.11.2.20)
- Video Call - Neuropsychological Battery Worksheets (v.11.2.20)
- Video Call - MiNT Stimuli PowerPoint presentation (v.11.2.20)
- Telephone - Neuropsychological Battery Worksheets (v.11.2.20 )
- NP Battery Required Assessments before Administration
- Short Physical Performance Battery (SPPB)
- Fazekas Rating Guidelines
- Recorded Fazekas Scoring Webinar
(Linked file auto-downloads to your computer. Please view in presentation mode to hear audio.)
- Online Fazekas Rater Test (Set 1)
(You may only take this test set once. If you do not pass with a minimum score of 80%, the coordinating center will contact you to take a different test-set)
- Recorded Fazekas Scoring Webinar
- Patient Enrollment Log Template (v10.23.18)
Consortium research sites are asked to email hsingh6@mgh.harvard.edu for additional required training certification steps, policies, and procedures.
- Fluid Best Practices (v2.12.20)
- Fluid Biosample Requirements (v2.12.20)
- Shipping Human Biospecimens Guideline (v2.12.20) To request the FedEx-MarkVCID login and password, contact hsingh6@mgh.harvard.edu
- Template Biosample Manifest(Email your biosample manifest to the receiving site and hsingh6@mgh.harvard.edu)
- Virtual Biorepository Guides
Consortium research sites are asked to email hsingh6@mgh.harvard.edu for additional required training certification steps, policies, and procedures.
- Initial Site Qualification Procedure (v.11.29.18)
- Imaging Analysis Requirements (v.11.30.18)
- Imaging Data Registration SOP (v.3.20.19)
- DICOM Data Anonymization SOP (v.1.21.20)
- Globus Installation & File Transfer SOP (v.11.9.20)
- Anonymization script (anon_for_markvcid.das)(v.10.2.18)
- MarkVCID Imaging DocID Log Template (v.10.23.18)
ME-MPRAGE
- Siemens (Trio): MPRAGE 11.15.18 (acquisition time = 6:03)
- Siemens (Prisma): MEMPRAGE pdf 2.3.18 (MEMPRAGE exar1) (5:53)
- Philips (Achieva): MPRAGE 2.12.18 (5:26)
FLAIR
- Siemens (Trio): FLAIR 11.15.18 (6:38)
- Siemens (Prisma): T2-Space FLAIR pdf 2.3.18 (T2-Space FLAIR exar1) (6:27)
- Philips (Achieva): FLAIR 3.25.19 (5:55)
Diffusion
- Siemens (Trio)
- DTI AP updated 7.29.19 (1:28)
- DTI PA 11.15.18 (7:50)
- DTI (Prisma): DTI 11.6.18 (PA = 7:01, AP = 1:00)
- Philips (Achieva)
- DTI-Philips 9.10.18 (PA = 7:14)
- DTI-Philips 11.20.18 (AP = 1:32)
- DTI-Philips Vectors 9.10.18
3D GRE & QSM
- Siemens (Trio): GRE 11.15.18 (5:09)
- Siemens (Prisma): QSM T2star - 8 echos - mono - 11.19.18 (6:18)
- Philips (Achieva): QSM 2.7.18 (5:23)
T2-weighted
- Siemens (Trio): T2W 11.15.18 (4:26)
- Siemens (Prisma): T2 Space 7.16.18 (4:14)
- Philips (Achieva): T2 SPACE 2.9.18 (3:18)
Cerebrovascular Reactivity (CVR)
- Siemens (Trio): CVR 9.10.18 (7:17)
- Siemens (Prisma): Siemens CVR_UH3_TR1500_9.7.18 )(7:17)
- Philips (Achieva): Philips_CVR_UH3_TR1500_9.7.18 (7:13)
T1-weighted
- Philips - IIT/Rush
- Trio - UNM
- Prisma - USC
Diffusion-weighted
- Philips - IIT/Rush
- Trio - UNM
- Prisma - USC
Functional MRI
- Philips - IIT/Rush
- Trio - UNM
- Prisma - USC
MRI ARTS
- MRI ARTS Kit Protocol (v.3.15.21)
- ARTS Biomarker Kit Software (v.3.15.21)
- MarkVCID ARTS Biomarker Kit Software Training Video (v.3.15.21)
MRI Cerebrovascular Reactivity
MRI White Matter Hyperintensity Volume
- MRI WMH Volume Protocol (v2_1.17.19)
- WMH Volume Webinar PPT (v.2.12.20)
- Click here for the WMH Volume analysis code
- Click here for WMH Volume algorithm video tutorial
MRI White Matter Hyperintensity Growth/Regression
- MRI WMH Growth/Regression Kit Protocol (v.3.31.20)
- WMH Growth/Regression Instructions (v.7.24.20)
- WMH Growth/Regression Scripts (v.7.24.20)
- WMH Growth/Regression Training PPT (v.7.24.20)
- WMH Growth/Regression Recorded Webinar (v.7.24.20)
MRI Peak Skeletonized Mean Diffusivity (PSMD)
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Supporting Documents:
- PSMD Video Tutorial (v3.11.20)
MRI Free Water
- MRI Free Water Kit Protocol (v10.30.19)
- Click here for Free Water Scripts
- FW Video Tutorial (v3.11.20)
OCTA Retinal Vessel Skeleton Density (VSD)
Plasma Endothelial Signaling Biomarker Kit
Plasma Exosome Endothelial Inflammation
- Plasma Exosome Endothelial Inflammation Kit Protocol (v10.28.19)
- Appendix 1 PPP Procedures (v.10.28.19)
- Appendix 2 EDE Isolation Procedures (v.10.28.19)
- Equipment & Consumables List (v.10.18.19)
Plasma Neurofilament Light (NfL)
- Plasma NfL Kit Protocol (v10.30.19)
- MarkVCID NfL Lab Protocol and Instrumental Validation (v.3.5.20)
- Plasma & Serum Sample Clarification - UVM Procedure (v.3.5.20)
CSF Placental Growth Factor (PLGF)
Data Use Agreement (for external investigators)
Note: Kit validation currently in progress. All kit protocols should be considered in draft form until validation is complete.
Questions/comments? Contact the Coordinating Center at hsingh6@mgh.harvard.edu
